Nicholas P. Franks

This study shows that amyloid accumulation in medial septal cholinergic neurons of aging mice leads to REM sleep loss, cognitive and emotional deficits, and amyloid spread to other brain regions.

This paper identifies a REM-active basal ganglia circuit in mice that regulates REM sleep and anxiety by showing its role in sleep duration and behavioral responses to aversive stimuli.

The paper identifies NOS1 neurons in the preoptic hypothalamus as sleep-active and shows they regulate NREM and REM sleep and body temperature.

This study shows that NMDA receptors in the hypothalamus are critical for stabilizing NREM sleep and enabling REM sleep by regulating calcium signals and neural activity.

The paper identifies a circuit pathway in mice where sleep-deprived prefrontal cortex neurons trigger nesting and sleep via connections to the preoptic and hypothalamus.

This study shows that dysfunction of VTA GABA neurons leads to mania-like behaviors, including increased wakefulness and reduced sleep, which can be reversed by valproate.

This study shows that galanin neurons in the hypothalamus regulate sleep homeostasis, body temperature, and the effects of dexmedetomidine.

The paper identifies nNOS-expressing neurons in the VTA and SNc as either GABAergic local interneurons or glutamatergic projection neurons, depending on their sub-region.