TREM2 agonist antibody rebuilds the resident synovial macrophage lining barrier in rheumatoid arthritis
Huihui Yuan, Jingyun Wang, Qichao Wang, Le Jiang, Leixin Liu, Weicheng Shen, Peixia Li, Wanting Liu, Ziyu Liu, Fanlei Hu, Xu Cai, Wanli Liu, Qiong Wu, Xiumei Wang, Hao Yan, Xiaodan Sun
This study shows that a TREM2 agonist antibody rebuilds the synovial macrophage lining barrier in RA by shifting macrophage states toward a barrier-like phenotype.
bioRxiv · Feb 5, 2026 · PreprintBioengineering