Qiong Wu

RNAverse, a multimodal generative model, designs functional RNAs with high performance across tasks, outperforming existing methods and enabling applications in gene therapy and vaccine development.

This study identifies ZNF638 as a host factor that represses HBV transcription by recruiting the HUSH complex to induce H3K9me3 histone modifications, thereby silencing cccDNA and reducing viral propagation.

This study shows that a TREM2 agonist antibody rebuilds the synovial macrophage lining barrier in RA by shifting macrophage states toward a barrier-like phenotype.

This study engineers glycogen metabolism in mesenchymal stem cells to improve their survival during starvation and therapeutic efficacy in pulmonary fibrosis.

This study shows that probiotic effectiveness in experimental colitis varies with individual microbiome and host genetic features, particularly TLR2.