Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA
Ekaterina Pisareva, Lucia Mihalovičová, Brice Pastor, Andrei Kudriavtsev, Alexia Mirandola, Thibault Mazard, Stéphanie Badiou, Ulrich A. Maus, Lena Ostermann, Julia Weinmann‐Menke, Elmo W. I. Neuberger, Perikles D. Simon, Alain Roger Thierry
This paper demonstrates that neutrophil extracellular traps (NETs) are a major source of mono-N cirDNA independent of apoptosis, and shows that NE and MPO contribute to NET autocatabolism and cirDNA release.
Genome Medicine · Nov 28, 2022Peer-reviewedMolecular Biology