Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s disease
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly M. Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Louise Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna J. Stevenson, , Tara L. Spires‐Jones
This study shows that reducing tau improves behavioural and transcriptional issues in a mouse model of Alzheimer’s disease, suggesting synaptic tau reduction could be a therapeutic strategy.
bioRxiv · Aug 16, 2018 · PreprintNeuroscience