Development of an RNA Aptamer as a Therapeutic Agent for Synucleinopathies
Kazuma Murakami, Thi Hong Van Nguyen, Leo Tsuda, Esha Chawla, Yangxia Wang, Yiran Chen, Nadia Stefanova, Chioko Nagao, Kenji Mizuguchi, Shouvik Manna, Samir Kumar Maji, Hidehito Tochio, Gal Bitan
This paper develops an RNA aptamer, 1R6, that targets synuclein and shows therapeutic potential in synucleinopathies by inhibiting aggregation and promoting disaggregation.
Nature Communications · Jul 15, 2026Peer-reviewedNeuroscience