Author

Leo Y. C. Yan

Chinese University of Hong Kong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:DNA methylation· 1

Frequent Co-Authors

Ho KoiD· 3 shared Junzhe HuangiD· 3 shared Vincent MokiD· 3 shared Zhongqi LiiD· 3 shared Bonaventure Yiu Ming IpiD· 2 shared H. M. LaiiD· 2 shared Joaquim S. L. VongiD· 2 shared Lei ZhaoiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Ho KoORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintMay 6, 2024

Functional and multi-omic aging rejuvenation with GLP-1R agonism

Junzhe Huang, Andrew John Kwok, Jason Chak Yan Li…·Ho Ko

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

6 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 21, 2020

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong…·Ho Ko

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

DOI 10.1101/2020.12.21.423879

humanbulk RNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedSep 4, 2020

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

Lei Zhao, Zhongqi Li, Joaquim S. L. Vong…·Ho Ko

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.

127 citationstop 3%

𝕏 PostBluesky