Ho Ko

Microbial colonization establishes stratified radial niches that coordinate host epithelial and immune maturation in the colon

This study shows microbial colonization creates stratified niches in the colon that coordinate host epithelial and immune maturation through spatial organization.

nELAVL phosphorylation by CDKL5 regulates RNA metabolism and condensates communication to promote experience-dependent maturation of the visual cortex

This study identifies CDKL5-mediated phosphorylation of nELAVL as critical for regulating RNA metabolism and condensate communication, essential for visual cortex maturation.

Pallium tracks valence-specific chemosensory amplification of eye-body coordination in larval zebrafish

This study shows how chemosensory cues affect eye-body coordination in larval zebrafish, with aversive cues enhancing coordination and food cues promoting forward movement.

Functional and multi-omic aging rejuvenation with GLP-1R agonism

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

Single-cell analysis of microglial transcriptomic diversity in subarachnoid hemorrhage

The paper uses single-cell RNA sequencing to analyze microglial transcriptomic diversity in subarachnoid hemorrhage, identifying distinct subgroups and their roles in neuroinflammation.

A neural circuit basis for binasal input-enhanced chemosensory avoidance

This study investigates how larval zebrafish integrate binasal chemosensory inputs to guide avoidance behavior using microfluidics and brainwide imaging.

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.