Junzhe Huang

This study characterizes the phenotypic effects of MYBPC3-A31P mutation in Maine Coon cats, showing gene-dose effects on cardiac structure and function, with homozygous cats exhibiting more severe features.

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.