Author

Joaquim S. L. Vong

Chinese University of Hong KongORCID 0000-0002-5859-2008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. M. LaiiD· 2 shared Ho KoiD· 2 shared Junzhe HuangiD· 2 shared Lei ZhaoiD· 2 shared Leo Y. C. Yan· 2 shared Vincent MokiD· 2 shared Xinyi CheniD· 2 shared Zhongqi LiiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

H. M. LaiORCID

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3 papers

Recent·Most cited

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and disease

Tianming Wu, Hao Yu, Brian Shing‐Hei Wong, Kexin Teng, Weiman Xiang, L. Xu, Jianan Zhang, Angel Y.F. Kam, Ethel S.K. Ng, Joaquim S. L. Vong, Jiannan Zhang, Bo Gao, S Y Tsui, Stephen Dalton

The paper describes human trunk embryoids that mimic posterior trunk development and uses them to study developmental processes and disease mechanisms.

bioRxiv · Dec 22, 2025 · PreprintDevelopmental Biology

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Yiu Ming Ip, Yun Kwok Wing, H. M. Lai, Vincent Mok, Ho Ko

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

bioRxiv · Dec 21, 2020 · PreprintNeuroscience

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

Lei Zhao, Zhongqi Li, Joaquim S. L. Vong, Xinyi Chen, H. M. Lai, Leo Y. C. Yan, Junzhe Huang, Samuel K. H. Sy, Xiao Yu Tian, Yü Huang, Ho Yin Edwin Chan, Hon‐Cheong So, Wai‐Lung Ng, Yamei Tang, Wei‐Jye Lin, , Ho Ko

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.

Nature Communications · Sep 4, 2020Peer-reviewedNeuroscience