The paper uses single-cell RNA sequencing to analyze microglial transcriptomic diversity in subarachnoid hemorrhage, identifying distinct subgroups and their roles in neuroinflammation.

bioRxiv · Dec 27, 2021 · PreprintNeuroscience

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Yiu Ming Ip, Yun Kwok Wing, H. M. Lai, Vincent Mok, Ho Ko

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

bioRxiv · Dec 21, 2020 · PreprintNeuroscience

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

Lei Zhao, Zhongqi Li, Joaquim S. L. Vong, Xinyi Chen, H. M. Lai, Leo Y. C. Yan, Junzhe Huang, Samuel K. H. Sy, Xiao Yu Tian, Yü Huang, Ho Yin Edwin Chan, Hon‐Cheong So, Wai‐Lung Ng, Yamei Tang, Wei‐Jye Lin, , Ho Ko

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.

Nature Communications · Sep 4, 2020Peer-reviewedNeuroscience