A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells
William C. W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C.G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wróblewska, M Kellis, Lin Zhang, Ron Weiss, Timothy K. Lu
The paper introduces a CRISPR-based synthetic transcription system for programmable gene expression in mammalian cells, demonstrating its ability to control gene activity and cellular functions with high tunability.
Nature Communications · Oct 18, 2022Peer-reviewedSynthetic Biology