Author

Gigi C.G. Choi

Massachusetts Institute of TechnologyORCID 0000-0003-2774-9188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Jicong CaoiD· 2 shared M KellisiD· 2 shared Timothy K. LuiD· 2 shared William C. W. CheniD· 2 shared Alan S.L. WongiD· 1 shared Claudia C. Wehrspaun· 1 shared Dianbo LiuiD· 1 shared Eva Maria NovoaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

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10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

Jicong CaoORCID

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2 papers

Recent·Most cited

Synthetic BiologyNature CommunicationsPeer-reviewedOct 18, 2022

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells

William C. W. Chen, Leonid Gaidukov, Yong Lai…·Timothy K. Lu

The paper introduces a CRISPR-based synthetic transcription system for programmable gene expression in mammalian cells, demonstrating its ability to control gene activity and cellular functions with high tunability.

36 citations

humanCRISPR screen

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Synthetic BiologyNature CommunicationsPeer-reviewedJul 6, 2021

High-Throughput 5' UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies

Jicong Cao, Eva Maria Novoa, Zhizhuo Zhang…·Timothy K. Lu

This study develops a high-throughput method to engineer 5' UTRs that enhance protein expression in non-viral gene therapies, identifying synthetic 5 UTRs that outperform existing plasmids.

161 citationstop 1%

statistical modelsimulation

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