Author

William C. W. Chen

Massachusetts Institute of TechnologyORCID 0000-0002-6891-3557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Synthetic Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Gigi C.G. ChoiiD· 2 shared Jicong CaoiD· 2 shared M KellisiD· 2 shared Timothy K. LuiD· 2 shared Alan S.L. WongiD· 1 shared Claudia C. Wehrspaun· 1 shared Dianbo LiuiD· 1 shared Eva Maria NovoaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Gigi C.G. ChoiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells

William C. W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C.G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wróblewska, M Kellis, Lin Zhang, Ron Weiss, Timothy K. Lu

The paper introduces a CRISPR-based synthetic transcription system for programmable gene expression in mammalian cells, demonstrating its ability to control gene activity and cellular functions with high tunability.

Nature Communications · Oct 18, 2022Peer-reviewedSynthetic Biology

High-Throughput 5' UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies

Jicong Cao, Eva Maria Novoa, Zhizhuo Zhang, William C. W. Chen, Dianbo Liu, Gigi C.G. Choi, Alan S.L. Wong, Claudia C. Wehrspaun, M Kellis, Timothy K. Lu

This study develops a high-throughput method to engineer 5' UTRs that enhance protein expression in non-viral gene therapies, identifying synthetic 5 UTRs that outperform existing plasmids.

Nature Communications · Jul 6, 2021Peer-reviewedSynthetic Biology