Yong Lai

DAPE-PD adapts a genomic foundation model into a diffusion model to generate functional cis-regulatory DNA sequences across three non-model gut commensals.

The paper describes the creation of SINERGY, a synthetic sourdough starter using engineered microbial consortia with division-of-labor modules for biosensing and drug delivery.

The paper introduces a CRISPR-based synthetic transcription system for programmable gene expression in mammalian cells, demonstrating its ability to control gene activity and cellular functions with high tunability.

This paper develops an ingestible capsule that detects short-lived inflammatory biomarkers in the GI tract using genetically engineered probiotic biosensors and wireless readout technology.

The paper develops a Cas9-assisted biocontainment system for engineered bacteria to prevent gene dissemination and ensure controlled expression in the gut.

The paper introduces CapQuant, a mass spectrometry-based method to analyze RNA caps, revealing new cap structures and variations in humans and mice.