Jicong Cao

Deep generative models generate mRNA sequences with enhanced translation capacity and stability

GEMORNA generates mRNA sequences with enhanced translation capacity and stability, showing significant improvements in expression levels and therapeutic applications.

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells

The paper introduces a CRISPR-based synthetic transcription system for programmable gene expression in mammalian cells, demonstrating its ability to control gene activity and cellular functions with high tunability.

High-Throughput 5' UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies

This study develops a high-throughput method to engineer 5' UTRs that enhance protein expression in non-viral gene therapies, identifying synthetic 5 UTRs that outperform existing plasmids.

Single-Nucleotide-Resolution Computing and Memory in Living Cells

The paper introduces a programmable read-write head for genomic DNA at single-nucleotide resolution, enabling scalable and robust computing and memory operations in living cells.