Constitutive ATR Signaling Enforces Domain-Wide Origin Synchrony
Joyce Kamar, Sharon Eden, Sunil Kumar Pradhan, Maruthi Kumar Pabba, María del Carmen Guerrero Arroyo, Avraham Greenberg, Leonor Daniel, M. Cristina Cardoso, Itamar Simon
The paper shows that constitutive ATR signaling coordinates replication origin firing across domains, and stress disrupts this coordination by sequestering ATR.
bioRxiv · Oct 20, 2026 · PreprintMolecular Biology