Maria Arroyo

The paper shows that constitutive ATR signaling coordinates replication origin firing across domains, and stress disrupts this coordination by sequestering ATR.

The paper investigates how heterochromatin proteins form barrier compartments in cells, showing differences between proteins, cell types, and compartments, and proposes a model based on protein accumulation and competition.

This study tracks replisome dynamics under replication stress using live-cell imaging, showing polymerase accumulation, clamp loading near stalled forks, and preferential restart at new origins after stress removal.

This study shows TET dioxygenases localize at splicing speckles and promote RNA splicing through interactions with splicing factors and cytosine modifications.

The paper shows MeCP2 increases nuclear stiffness during differentiation, and this effect is disrupted by Rett syndrome mutations, correlating with disease severity.