Itamar Simon

The paper shows that constitutive ATR signaling coordinates replication origin firing across domains, and stress disrupts this coordination by sequestering ATR.

The paper introduces a novel dual-spike-in normalization method for ChIP-seq, demonstrating its ability to clarify the relationship between RNA polymerase II activity and histone modifications.

This study identifies RBM10's role in DNA replication and shows that targeting WEE1 can sensitize RBM10-deficient lung adenocarcinoma cells.

The paper analyzes 2,787 tumors to show that replication timing and mutation rate association is influenced by both cell autonomous and non-autonomous processes, including DNA repair, chromatin structure, and immune cell interactions.

This study identifies ASF1 as a partner of RIF1 that promotes NHEJ by compacting chromatin and suppressing resection in BRCA1-deficient cells.

The paper analyzes mutational signatures in tumors to determine their association with replication timing and chromatin accessibility, finding signature-specific associations and clinical relevance of SBS16 in liver cancer.

The paper investigates mitotic bookmarking through histone modifications and nucleosome deposition patterns in human cells, showing that epigenomic landscapes and modified nucleosomes contribute to chromatin reestablishment after mitosis.

The paper measures DNA replication timing in mouse germline cells and shows it strongly correlates with mutation rates, recombination hotspots, and genomic features compared to somatic tissues.