M. Cristina Cardoso

The paper shows that constitutive ATR signaling coordinates replication origin firing across domains, and stress disrupts this coordination by sequestering ATR.

The paper investigates how heterochromatin proteins form barrier compartments in cells, showing differences between proteins, cell types, and compartments, and proposes a model based on protein accumulation and competition.

This study tracks replisome dynamics under replication stress using live-cell imaging, showing polymerase accumulation, clamp loading near stalled forks, and preferential restart at new origins after stress removal.

RepliCNN predicts DNA replication timing and related features from strand-specific 3' DNA end sequencing data with high accuracy.

The paper develops a DNA labeling technique to study chromatin mobility and organization during neural differentiation, finding reduced chromatin mobility and increased compaction in differentiated cells.

This study shows TET dioxygenases localize at splicing speckles and promote RNA splicing through interactions with splicing factors and cytosine modifications.

The paper shows MeCP2 increases nuclear stiffness during differentiation, and this effect is disrupted by Rett syndrome mutations, correlating with disease severity.

This study identifies RIF1 as a molecular hub that co-regulates nuclear organisation and replication timing through its interaction with PP1, revealing distinct functional requirements for these processes.

This study shows that FUS-dependent liquid-liquid phase separation is essential for early DNA damage response activation and repair complex assembly.