Maruthi Kumar Pabba

The paper shows that constitutive ATR signaling coordinates replication origin firing across domains, and stress disrupts this coordination by sequestering ATR.

This study tracks replisome dynamics under replication stress using live-cell imaging, showing polymerase accumulation, clamp loading near stalled forks, and preferential restart at new origins after stress removal.

RepliCNN predicts DNA replication timing and related features from strand-specific 3' DNA end sequencing data with high accuracy.

The paper develops a DNA labeling technique to study chromatin mobility and organization during neural differentiation, finding reduced chromatin mobility and increased compaction in differentiated cells.

The paper shows MeCP2 increases nuclear stiffness during differentiation, and this effect is disrupted by Rett syndrome mutations, correlating with disease severity.