Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington's Disease Mouse Striatum
Sandra M. Holley, Jack C. Reidling, Carlos Cepeda, Alice Lau, Cindy Moore, Iliana Orellana, Brian Fury, Lexi Kopan, Sylvia Y. Yeung, Michael J. Neel, Dane Coleal‐Bergum, Edwin S. Monuki, Charles K. Meshul, Gerhard Bauer, Michael S. Levine, Leslie Michels Thompson
This study shows that human neural stem cells transplanted into Huntington's disease mouse models improve behavior, reduce mutant Huntingtin, and integrate functionally into the host brain.
bioRxiv · Jan 18, 2021 · PreprintNeuroscience