Sandra M. Holley

The paper tracks and manipulates striatal neuron activity during goal-directed learning and habit formation, finding D1+ neurons maintain stable action representations while A2A+ neurons show transient or slow reorganization.

This paper examines corticostriatal development in the R6/2 mouse model of juvenile Huntington disease, finding early cortical malformations and transient synaptic deficits that normalize by postnatal day 21.

This study uses CRISPR-A to enhance expression of CHD8 and SCN2A in organoids, rescuing haploinsufficiency and associated phenotypes in ASD models.

This paper identifies a bidirectional corticoamygdala circuit that encodes and retrieves detailed reward memories in rats, showing its role in adaptive decision making.

This study shows that human neural stem cells transplanted into Huntington's disease mouse models improve behavior, reduce mutant Huntingtin, and integrate functionally into the host brain.