Author

Alice Lau

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Leslie Michels ThompsoniD· 4 shared Jack C. Reidling· 3 shared Nicolette R. McClureiD· 3 shared Ricardo MiramontesiD· 3 shared Andrea M. Reyes-OrtiziD· 2 shared Emily MiyoshiiD· 2 shared Jie WuiD· 2 shared Neethu Michael· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Leslie Michels ThompsonORCID

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Author profile →

4 papers

Recent·Most cited

Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification.

Thai B. Nguyen, Ricardo Miramontes, Carlos Chillón-Marinas, Roy Maimon, Sonia Vazquez‐Sanchez, Alice Lau, Nicolette R. McClure, Whitney England, Monika K. Singha, Jennifer T. Stocksdale, Ki-Hong Jang, Sunhee Jung, Jharrayne I. McKnight, Leanne N. Ho, Richard L. M. Faull, , Leslie Michels Thompson

This study identifies TDP-43 dysfunction and reduced m6A modification as mechanisms causing aberrant splicing in Huntington's disease using mouse and human brain data.

bioRxiv · Oct 31, 2023 · PreprintNeuroscience

Integrated transcriptome analysis of Huntingtons disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation

Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette R. Geller, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, Mathew M. Blurton-Jones, David Van Vactor, John C. Reidling, , Leslie Michels Thompson

This study compares HD astrocytes from human iPSCs and mouse models, identifying dysregulated synaptogenesis, actin signaling, and maturation, with unique human findings and potential therapeutic targets.

bioRxiv · Jul 28, 2022 · PreprintNeuroscience

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism

Ryan G. Lim, Osama Al‐Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Fatima Khan, Fahad Paryani, , Leslie Michels Thompson

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

bioRxiv · Jun 27, 2022 · PreprintNeuroscience

Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington's Disease Mouse Striatum

Sandra M. Holley, Jack C. Reidling, Carlos Cepeda, Alice Lau, Cindy Moore, Iliana Orellana, Brian Fury, Lexi Kopan, Sylvia Y. Yeung, Michael J. Neel, Dane Coleal‐Bergum, Edwin S. Monuki, Charles K. Meshul, Gerhard Bauer, Michael S. Levine, Leslie Michels Thompson

This study shows that human neural stem cells transplanted into Huntington's disease mouse models improve behavior, reduce mutant Huntingtin, and integrate functionally into the host brain.

bioRxiv · Jan 18, 2021 · PreprintNeuroscience