Angptl5 restricts primitive hematopoiesis by modulating retinoic acid signaling in zebrafish
Jinsong Mo, Dinghao Zhuo, Ying Huang, Tao Cheng, Yang Dong, Yan-Yi Xing, Yun-Fei Li, Zixin Jin, Xiang Liu, Guo-Qin Zhao, Hai-Rong Pu, Yu-Meng Liu, Zhixu He, Li-Ping Shu, Peng‐Fei Xu
This study identifies Angptl5 as a regulator of hematopoietic homeostasis in zebrafish by modulating retinoic acid signaling, leading to myeloid hyperplasia and erythroid expansion in mutants.
bioRxiv · Aug 18, 2025 · PreprintDevelopmental Biology