Ying Huang

Linking working memory maintenance and readout in monkey sensory and prefrontal cortex

This study identifies neurons in monkey auditory and prefrontal cortex that maintain tone-specific information during memory delay and later reflect behavioral decisions, challenging previous methods for identifying working memory neurons.

Angptl5 restricts primitive hematopoiesis by modulating retinoic acid signaling in zebrafish

This study identifies Angptl5 as a regulator of hematopoietic homeostasis in zebrafish by modulating retinoic acid signaling, leading to myeloid hyperplasia and erythroid expansion in mutants.

Effect of Caenorhabditis elegans U6 Promoters on CRISPR/Cas9-Mediated Gene Editing Efficiency

This study evaluates C. elegans U6 promoters' impact on CRISPR/Cas9 gene editing efficiency, identifying four superior promoters that enhance editing outcomes.

Leveraging Multi-Modal Feature Learning for Predictions of Antibody Viscosity

This paper predicts antibody viscosity using a multimodal feature learning approach integrating sequence, structural, and physicochemical data with language model embeddings.

BMP4 is sufficient to induce a caudal organizer

This study shows that BMP4 alone can induce a caudal organizer in zebrafish embryos and human pluripotent stem cells, replicating developmental processes seen in natural development.

Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

The paper shows that Ripply1 and Gsc suppress anterior endoderm differentiation from prechordal plate progenitors by repressing sox32 through cis-element binding.

Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1

This study uses a zebrafish model of Feingold syndrome 1 to show that Mycn regulates intestinal development through ribosomal biogenesis and that leucine supplementation can rescue the intestinal defect.

Iron promotes Slc7a11-deficient valvular interstitial cell osteogenic differentiation: A possible mechanism by which ferroptosis participates in intraleaflet hemorrhage-induced calcification.

This paper investigates how iron promotes osteogenic differentiation of Slc7a11-deficient valvular interstitial cells through ferroptosis, contributing to aortic valve calcification.

Single cell response landscape of graded Nodal signaling in zebrafish explants

The paper constructs a single-cell response landscape to graded Nodal signaling in zebrafish explants, identifies 105 immediate targets, and shows Nodal can induce axial mesoderm and head structure but not internal endoderm.

SMRT sequencing of the Oryza rufipogon genome reveals the genomic basis of rice adaptation

The paper presents a high-quality Oryza rufipogon genome assembly using SMRT sequencing and identifies genomic variants and selected genes related to reproductive traits and adaptation.