Tao Cheng

Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics

The paper introduces Palette, a method to infer spatial gene expression from bulk RNA-seq data, and constructs DreSTEP, a resource for studying gene expression and spatial interactions in zebrafish embryos.

Mycn regulates vascular development through PI3K signaling pathway in zebrafish

This study shows Mycn regulates vascular development in zebrafish by promoting cell proliferation and that PI3K signaling can rescue vascular defects caused by Mycn deficiency.

Angptl5 restricts primitive hematopoiesis by modulating retinoic acid signaling in zebrafish

This study identifies Angptl5 as a regulator of hematopoietic homeostasis in zebrafish by modulating retinoic acid signaling, leading to myeloid hyperplasia and erythroid expansion in mutants.

BMP4 is sufficient to induce a caudal organizer

This study shows that BMP4 alone can induce a caudal organizer in zebrafish embryos and human pluripotent stem cells, replicating developmental processes seen in natural development.

Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

The paper shows that Ripply1 and Gsc suppress anterior endoderm differentiation from prechordal plate progenitors by repressing sox32 through cis-element binding.

Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1

This study uses a zebrafish model of Feingold syndrome 1 to show that Mycn regulates intestinal development through ribosomal biogenesis and that leucine supplementation can rescue the intestinal defect.

Single cell response landscape of graded Nodal signaling in zebrafish explants

The paper constructs a single-cell response landscape to graded Nodal signaling in zebrafish explants, identifies 105 immediate targets, and shows Nodal can induce axial mesoderm and head structure but not internal endoderm.