Microcircuit failure in STXBP1 encephalopathy leads to hyperexcitability
Altair Brito dos Santos, Silas Dalum Larsen, Liangchen Guo, Paola Barbagallo, Alexia Montalant, Matthijs Verhage, Jakob Balslev Sørensen, Jean‐Françóis Perrier
This study identifies excitatory synapse dysfunction in microcircuits as the cause of hyperexcitability in Stxbp1 haploinsufficiency and shows that ampa-kines can rescue this defect.
Cell Reports Medicine · Dec 1, 2023Peer-reviewedNeuroscience