Matthijs Verhage

The paper shows that 4-HNE increases SYT1 expression in macrophages, which inhibits phagocytosis of bacteria.

This study develops a single-step transposon-based method to generate pure GABAergic neurons from iPSCs, showing they mature synaptically and form functional networks.

This study shows Rab10 maintains Ca2+ homeostasis and protein synthesis to regulate neuropeptide release via DCVs in mouse hippocampal neurons.

The paper shows that ER Ca2+ depletion in mouse neurons reduces DCV exocytosis by inhibiting L-type Ca2+ channels via a STIM1-dependent feedback loop, while not affecting SV exocytosis.

This study identifies rabphilin-3A as a negative regulator of DCV exocytosis through its interaction with SNAP25, showing increased DCV release in its absence.

This study investigates the role of KIF5A in axonal transport and repair in human motor neurons, finding that its loss impairs mitochondrial and SFPQ granule transport and axonal regeneration.

This study shows tomosyns inhibit synaptic depression by binding to VAMP2-containing template complexes and preventing SNAP-25 association, rather than competing with VAMP2 for SNARE complex assembly.

This study shows that SNX4 limits synaptic vesicle docking and release by affecting active zone structure and vesicle density.

This study identifies excitatory synapse dysfunction in microcircuits as the cause of hyperexcitability in Stxbp1 haploinsufficiency and shows that ampa-kines can rescue this defect.

This study shows that tomosyn regulates DCV cargo levels but not exocytosis in neurons, suggesting a role in cargo production rather than release.

This study combines Ngn2 overexpression with small molecule patterning to efficiently generate lower induced Motor Neurons (liMoNes) from hPSCs, achieving high yields and functional characteristics.

The paper identifies synaptic gene sets that can discriminate cortical neuronal identities with the same power as all genes, revealing functional categories and compartments with cell type-specific expression.

The paper investigates the trafficking of three organelle markers in thalamocortical axons in vivo, finding differences in speed and behavior compared to in vitro studies.

The paper shows that post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1, enhancing release rates through additive mechanisms.

This study identifies retrograde transport defects in MUNC18-1 null neurons as the cause of abnormal Golgi morphology and neurodegeneration.

The paper introduces a Bayesian framework to prioritize risk genes for complex diseases by integrating gene-set information with variant counts, identifying novel epilepsy risk genes and linking them to immune pathways and drug targets.

The paper visualizes and quantifies dense core vesicle (DCV) trafficking in axons of anesthetized and awake mice, finding faster maximal speeds and lower pausing fraction in vivo compared to in vitro studies.

The paper uses Bayesian modeling to analyze rare exonic variants in schizophrenia and neurodevelopmental disorders, identifying 1,551 risk genes for schizophrenia and 98 new risk genes for developmental disorders.