Author

Paola Barbagallo

John Radcliffe HospitalORCID 0000-0002-4361-8973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alexia MontalantiD· 1 shared Altair Brito dos SantosiD· 1 shared Ana CandalijaiD· 1 shared Andrew G. L. DouglasiD· 1 shared David SimsiD· 1 shared Jakob Balslev SørenseniD· 1 shared Jakub ScaberiD· 1 shared Jean‐Françóis PerrieriD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

Alexia MontalantORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Microcircuit failure in STXBP1 encephalopathy leads to hyperexcitability

Altair Brito dos Santos, Silas Dalum Larsen, Liangchen Guo, Paola Barbagallo, Alexia Montalant, Matthijs Verhage, Jakob Balslev Sørensen, Jean‐Françóis Perrier

This study identifies excitatory synapse dysfunction in microcircuits as the cause of hyperexcitability in Stxbp1 haploinsufficiency and shows that ampa-kines can rescue this defect.

Cell Reports Medicine · Dec 1, 2023Peer-reviewedNeuroscience

Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair

Nidaa A. Ababneh, Jakub Scaber, Rowan Flynn, Andrew G. L. Douglas, Paola Barbagallo, Ana Candalija, Martin R. Turner, David Sims, Ruxandra Dafinca, Sally A. Cowley, Kevin Talbot

This study corrects a C9orf72 hexanucleotide expansion in iPSC-derived motor neurons using CRISPR/Cas9 and HDR, restoring normal gene expression and eliminating pathological phenotypes.

Human Molecular Genetics · Jun 1, 2020Peer-reviewedNeuroscience