Author

Liangchi Zhou

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:CRISPR screen· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Evgueni A. IvakineiD· 2 shared Reid A. Brewer· 2 shared Ronald D. CohniD· 2 shared Steven Erwood· 2 shared Teija M.I. BilyiD· 2 shared Eleonora MainoiD· 1 shared Jason LequyeriD· 1 shared Joyce YaniD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersGenetics

Evgueni A. IvakineORCID

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2 papers

Recent·Most cited

Saturation variant interpretation using CRISPR prime editing

Steven Erwood, Teija M.I. Bily, Jason Lequyer, Joyce Yan, Nitya Gulati, Reid A. Brewer, Liangchi Zhou, Laurence Pelletier, Evgueni A. Ivakine, Ronald D. Cohn

The paper uses CRISPR prime editing to functionally interpret variants in NPC1 and BRCA2 genes by haploidizing cell lines and scoring 256 and 465 variants respectively.

Nature Biotechnology · Feb 21, 2022Peer-reviewedGenetics

Modelling Niemann-Pick disease type C in a human haploid cell line allows for patient variant characterization and clinical interpretation.

Steven Erwood, Reid A. Brewer, Teija M.I. Bily, Eleonora Maino, Liangchi Zhou, Ronald D. Cohn, Evgueni A. Ivakine

This paper develops a haploid cell model for Niemann-Pick disease type C to characterize patient variants and enable clinical interpretation.

Genome Research · Dec 1, 2019Peer-reviewedGenetics