Nitya Gulati

Apollo-IRE1 is a genetically encoded sensor that detects ER stress by measuring IRE1 oligomerization and fluorescence anisotropy changes, enabling multiplexed imaging in living cells.

The paper develops an on-chip fluorescence anisotropy immunoassay for human C-peptide by optimizing antibody-tracer pairs to achieve high sensitivity and fast kinetics for microfluidic measurement.

This study shows that free cholesterol accumulation in macrophages activates a PARP1 response to DNA damage, which suppresses lipopolysaccharide-induced inflammation through a non-enzymatic mechanism.

This paper develops a cryopreservation method for myoblasts in paper-based scaffolds, enabling inter-laboratory studies of skeletal muscle health.

FAST-STEM accelerates human pluripotent stem cell engineering by enabling rapid transgene integration and differentiation into multiple cell types.

This paper introduces a toolkit for transgene integration in hiPSCs using a safe-harbour locus, enabling controlled transgene configurations and efficient cellular engineering.

The paper uses CRISPR prime editing to functionally interpret variants in NPC1 and BRCA2 genes by haploidizing cell lines and scoring 256 and 465 variants respectively.