Author

Reid A. Brewer

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:variant effect prediction· 3 Assay:whole-exome sequencing· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Evgueni A. IvakineiD· 3 shared Liangchi Zhou· 2 shared Ronald D. CohniD· 2 shared Steven Erwood· 2 shared Teija M.I. BilyiD· 2 shared Athina GanneriD· 1 shared Chelsea SawyeriD· 1 shared Chloé TerwagneiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetics

Evgueni A. IvakineORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Saturation Genome Editing Resolves the Functional Spectrum of Pathogenic VHL Alleles

Megan Buckley, Chloé Terwagne, Athina Ganner, Laura Cubitt, Reid A. Brewer, Dong‐Kyu Kim, Christina M. Kajba, N. Forrester, Phoebe Dace, Joachim De Jonghe, Scott T.C. Shepherd, Chelsea Sawyer, Mairead McEwen, Sven Diederichs, Elke Neumann‐Haefelin, , Gregory M. Findlay

This study uses Saturation Genome Editing to functionally assess VHL variants, identifying pathogenic alleles and their mechanisms in cancer.

Nature Genetics · Jul 1, 2024Peer-reviewedGenomics

Saturation variant interpretation using CRISPR prime editing

Steven Erwood, Teija M.I. Bily, Jason Lequyer, Joyce Yan, Nitya Gulati, Reid A. Brewer, Liangchi Zhou, Laurence Pelletier, Evgueni A. Ivakine, Ronald D. Cohn

The paper uses CRISPR prime editing to functionally interpret variants in NPC1 and BRCA2 genes by haploidizing cell lines and scoring 256 and 465 variants respectively.

Nature Biotechnology · Feb 21, 2022Peer-reviewedGenetics

Modelling Niemann-Pick disease type C in a human haploid cell line allows for patient variant characterization and clinical interpretation.

Steven Erwood, Reid A. Brewer, Teija M.I. Bily, Eleonora Maino, Liangchi Zhou, Ronald D. Cohn, Evgueni A. Ivakine

This paper develops a haploid cell model for Niemann-Pick disease type C to characterize patient variants and enable clinical interpretation.

Genome Research · Dec 1, 2019Peer-reviewedGenetics