Liangzhong Lim

Misfolded proteins share a common capacity in disrupting LLPS organizing membrane-less organelles

The paper shows misfolded proteins can disrupt LLPS organizing membrane-less organelles by reducing their dynamics and potentially causing structural damage.

NMR studies reveal that protein dynamics critically mediate aggregation of the well-folded and very soluble E. coli S1 ribosomal protein

This study uses NMR and spectroscopy to show that dynamic inter-domain interactions and domain-level motions in E. coli S1 protein contribute to its aggregation propensity despite being well-folded and soluble.

RRM domain of ALS/FTD-causing FUS interacts with membrane: an anchor of membraneless organelles to membranes?

The paper investigates whether the RRM domain of FUS interacts with membranes, finding that it dynamically binds bicelles, suggesting a mechanism for organizing membraneless organelles with membranes.

Identification of a Zika NS2B-NS3pro pocket susceptible to allosteric inhibition by small molecules including qucertin rich in edible plants

The paper identifies two small molecules, including qucertin from edible plants, that inhibit Zika NS2B-NS3pro through allosteric binding, offering potential for anti-Zika drug development.

Unique properties of Zika NS2B-NS3pro complexes as decoded by experiments and MD simulations

This study characterizes the conformation, catalysis, inhibition, and dynamics of Zika NS2B-NS3pro complexes using experiments and MD simulations, revealing unique properties distinct from Dengue.

Identification of quercetin from fruits to immediately fight Zika

This study identifies quercetin as an inhibitor of Zika NS2B-NS3 protease with IC50 and Ki values of 26.0 and 23.0 μM, respectively, and highlights its availability in common foods.

Direct and Indirect Models for Protein Chemical Denaturation are Characteristic of Opposite Dynamic Properties

The paper differentiates the effects of GdmCl and NaSCN on protein denaturation using CD and NMR, showing they follow opposite dynamic properties.

Unlocked capacity of proteins to attack membranes characteristic of aggregation: the evil for diseases and aging from Pandora’s box

The paper investigates how protein aggregation in aging and disease unlocks membrane-interacting capacities, revealing that disrupted protein folds in E. coli and ALS-causing mutations expose hydrophobic regions that interact abnormally with membranes.

Mechanisms of self-assembly and fibrillization of the prion-like domains

This study investigates the self-assembly and fibrillization of prion-like domains, showing that these processes are sequence-dependent and not primarily governed by electrostatic interactions.

A novel SOD1-dependent mechanism for the iron-induced production of toxic SOD1 and oxidative stress that initiates ALS

The paper identifies a novel SOD1-dependent mechanism by which iron induces toxic SOD1 and oxidative stress, contributing to neurodegenerative diseases and aging.