Jian Kang

SCG: Spatially Co-Expressed Gene Identification through Spatially Varying Networks

This paper introduces SCR, a Bayesian framework for estimating spatially-resolved gene co-expression networks to identify spatially co-expressed genes as potential biomarkers and therapeutic targets.

Label free multimodal optical imaging of metabolic heterogeneity and correlation in aging by integrating SRS, MPF, FLIM, and SHG

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

Spatio-temporal mass spectrometry in living cells reveals regulators of cuproptosis

This study develops STMS to analyze subcellular proteomic changes during cuproptosis, identifies key regulators, and discovers potential inhibitors.

Local nucleolar surveillance mechanisms maintain rDNA stability

This study identifies localized nucleolar surveillance mechanisms that respond to rDNA damage by activating the nucleolar DNA damage response (nDDR) through R-loop formation and RAD54L protection.

Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility

This study shows that oxidative stress modifies miR-483 to 8OH-G miR-483, leading to endothelial dysfunction and increased atherosclerosis risk through altered targetomes.

Misfolded proteins share a common capacity in disrupting LLPS organizing membrane-less organelles

The paper shows misfolded proteins can disrupt LLPS organizing membrane-less organelles by reducing their dynamics and potentially causing structural damage.