Lu Wang

Creator 1.0: Phylogeny-Guided Stagewise Pretraining for Plant Genome Foundation Models across 1,000 Species

Creator 1.0 is a plant genome foundation model pretrained on 1,000 species using phylogeny-guided stagewise pretraining, achieving strong performance on plant-related tasks.

POU2AF2/OCA-T1 coactivates POU2F2 and defines a lineage-specific dependency in diffuse large B-cell lymphoma

This study identifies POU2AF2 as a lineage-specific dependency in DLBCL, showing it coactivates POU2F2 to sustain malignant transcriptional networks and innate-like B-cell identity.

Prevalence and Clinical Significance of Adult-Onset Cancer Predisposition Variants in Pediatric Oncology

The paper examines the prevalence and clinical significance of adult-onset cancer predisposition variants in pediatric cancer patients, finding most variants are secondary rather than directly related to the tumor.

Neuromodulation of Foxp2+ hypothalamic neurons induces therapeutic hypothermia

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

Kindlin-2-Moesin interaction orchestrates sprouting angiogenesis via modulating endothelial membrane mechanics and VEGF signaling

This study identifies Kindlin-2-Moesin interaction as a regulator of sprouting angiogenesis by modulating endothelial membrane tension and VEGF signaling.

Seq2Karyotype (S2K): A Method for in-silico Karyotyping Using Single-Sample Whole-Genome Sequencing Data

Seq2Karyotype (S2K) enables in-silico karyotyping from whole-genome sequencing data, revealing intratumoral heterogeneity and evolutionary trajectories in cancer samples.

Not alpha power: prestimulus beta power predicts the magnitude of individual temporal order bias for audiovisual stimuli

The paper investigates how prestimulus beta power in auditory and visual cortices predicts individual temporal order bias in audiovisual perception tasks.

Machine Learning Electroencephalography Biomarkers Predictive of Epworth Sleepiness Scale

This study uses machine learning to identify EEG biomarkers predictive of Epworth Sleepiness Scale scores, achieving over 80% accuracy in distinguishing high vs low ESS groups.

Mechanisms of self-assembly and fibrillization of the prion-like domains

This study investigates the self-assembly and fibrillization of prion-like domains, showing that these processes are sequence-dependent and not primarily governed by electrostatic interactions.