HDAC inhibitors rescue MeCP2T158M speckles in a high content screen
Rodrigo Lata, Liesbeth Steegmans, Ranie Kellens, Marnik Nijs, Hugo Klaassen, Matthias Versele, Frauke Christ, Zeger Debyser
The paper screens FDA-approved drugs and compounds to identify small molecules that rescue MeCP2-T158M speckle formation in NIH3T3 cells, finding HDAC inhibitors as effective rescuers.
bioRxiv · Nov 2, 2023 · PreprintNeuroscience