Co-targeting KRAS and BCL-2 induces pyroptosis and antitumor tertiary lymphoid structures
Xu Yang, Man Li, Jian Zhang, Danming He, Xu Liu, Lihui Liu, Jianchun Duan, Zhijie Wang, Hua Bai, Jie Wang
This study shows that combining KRAS and BCL-2 inhibition induces pyroptosis and tertiary lymphoid structures in KRAS G12D-mutant lung cancer, enhancing B-cell-dependent antitumor immunity.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology