Fragile polyQ assemblies cause Golgipathy in Huntington's disease
Lixiang Ma, Xinyu Chen, Yang Liu, Lijun Dai, Fangzhou Ye, Weiqi Yang, Hada Buhe, Jixin Ma, Chenyun Song, Li Li, Dandan Fan, Fanxun Chen, Haoman Chen, Jianwei Shuai, Jianzhong Su, Hexige Saiyin
This study identifies polyQ assemblies in HD cells as dynamic structures that regulate Golgi function, showing that mutant HTT disrupts their stability and leads to Golgipathy.
bioRxiv · Oct 6, 2024 · PreprintPathology