Long-read genome sequencing reveals complex variability in lentiviral provirus insertions in deeply characterized Clonal CD19 CAR-T vector copy number reference cell lines
Zhiyong He, Jennifer McDaniel, Linhua Tian, Mahir Mohiuddin, Ningchun Xu, Lili Wang, Justin M. Zook, Hua‐Jun He
The paper uses long-read sequencing to characterize lentiviral provirus insertions in clonal CAR-T cell lines, revealing structural variations missed by short-read and ddPCR methods.
bioRxiv · Jun 16, 2026 · PreprintGenomics