Transduction catalysis:doxorubicin accelerates and enhances rAAV-mediated gene expression in the cortex of mouse, cat and monkey
Hongliang Gong, Nini Yuan, Zhiming Shen, Cheng Tang, Stewart D. Shipp, Liling Qian, Yiliang Lu, Ian Max Andolina, Shenghai Zhang, Jihong Wu, Hui Yang, Wei Wang
This study shows doxorubicin enhances rAAV-mediated gene expression in the cortex of mice, cats, and monkeys, with effects observed across multiple serotypes and without significant cytotoxicity.
bioRxiv · Jun 8, 2020 · PreprintNeuroscience