Nini Yuan

CynoBrain provides a high-resolution framework for integrating multi-modal data in macaque brains, enabling cross-modal analysis and a unified reference space.

This study creates a single-cell spatial transcriptomic atlas of the human cortex, revealing gene expression patterns, aging effects, and disease associations across layers and species.

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

The paper creates a high-resolution spatial transcriptomic atlas of the mouse brain using snRNA-seq and Stereo-seq, identifying new cell clusters, region-specific genes, and transcription factor regulons.

This study shows doxorubicin enhances rAAV-mediated gene expression in the cortex of mice, cats, and monkeys, with effects observed across multiple serotypes and without significant cytotoxicity.