Combining interstrand crosslinking agents with histone deacetylase inhibitors against high grade IDH mutant gliomas
Thomas K. Sears, Lillian Coe, Rahul Kishore Chaliparambil, Wenxia Wang, Mateo Gomez, Matthew McCord, Andrew Li, Susan E. Gueble, ranjit bindra, Craig Horbinski
This study evaluates the efficacy of KL-50 and its combination with belinostat in IDHmut gliomas, showing enhanced cytotoxicity in MMR-deficient models and potential mechanisms involving DNA repair pathways and PKMYT1.
bioRxiv · Sep 29, 2026 · PreprintCancer Biology