Cancer BiologybioRxivPreprint
Combining interstrand crosslinking agents with histone deacetylase inhibitors against high grade IDH mutant gliomas
Thomas K. Sears, Lillian Coe, Rahul Kishore Chaliparambil…·Craig Horbinski
This study evaluates the efficacy of KL-50 and its combination with belinostat in IDHmut gliomas, showing enhanced cytotoxicity in MMR-deficient models and potential mechanisms involving DNA repair pathways and PKMYT1.
DOI 10.64898/2026.09.28.755068