Author

Susan E. Gueble

Yale UniversityORCID 0000-0002-8043-1147Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 1

Frequent Co-Authors

Ahmad KiwaniD· 1 shared Amro BaassiriiD· 1 shared Andrew Li· 1 shared Collin Heer· 1 shared Craig HorbinskiiD· 1 shared James Elia· 1 shared Jennifer VanOudenhoveiD· 1 shared Lillian Coe· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Ahmad KiwanORCID

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2 papers

Recent·Most cited

Combining interstrand crosslinking agents with histone deacetylase inhibitors against high grade IDH mutant gliomas

Thomas K. Sears, Lillian Coe, Rahul Kishore Chaliparambil, Wenxia Wang, Mateo Gomez, Matthew McCord, Andrew Li, Susan E. Gueble, ranjit bindra, Craig Horbinski

This study evaluates the efficacy of KL-50 and its combination with belinostat in IDHmut gliomas, showing enhanced cytotoxicity in MMR-deficient models and potential mechanisms involving DNA repair pathways and PKMYT1.

bioRxiv · Sep 29, 2026 · PreprintCancer Biology

Biomarker-Targeted O6-Guanine Alkylation Potentiates ATR Inhibitor Response in De Novo and Relapsed/Refractory AML

Prateek Bhardwaj, Amro Baassiri, Ranjini K. Sundaram, Sam Friedman, James Elia, Jennifer VanOudenhove, Collin Heer, Ahmad Kiwan, Martin Matthews, Susan E. Gueble, Stephanie Halene, Ranjit S. Bindra

This study identifies MGMT silencing as a therapeutic target in AML and shows that combining O6-fluoroethylating agents with ATR inhibitors improves treatment outcomes.

bioRxiv · Sep 22, 2026 · PreprintCancer Biology