A Drosophila Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in Neurons
Derrick Jerone Morton, Binta Jalloh, Lily Kim, Isaac Kremsky, Rishi J. Nair, Khuong B. Nguyen, J. Christopher Rounds, Maria C. Sterrett, Brianna E Brown, Thalia Le, Maya C. Karkare, Kathryn D. McGaughey, Shaoyi Sheng, Sara W. Leung, Milo B. Fasken, , Anita H. Corbett
This study uses a Drosophila model to show that mutations in EXOSC3 cause neuronal dysfunction by altering RNA exosome function and affecting key neuronal RNAs.
PLoS Genetics · Jul 9, 2020Peer-reviewedGenetics