Isaac Kremsky

The paper identifies millions of previously unknown genetic variants in CD-1 mice and constructs a strain-specific reference genome to improve sequencing accuracy and reduce bias.

This study identifies Nab2's role in regulating m6A-dependent splicing of Sxl in Drosophila neuronal tissue, linking it to developmental and behavioral phenotypes.

The paper creates a yeast model of SHRF mutations in EXOSC2 and compares it to an EXOSC3 mutation model, showing distinct RNA exosome functional impacts.

This study uses a Drosophila model to show that mutations in EXOSC3 cause neuronal dysfunction by altering RNA exosome function and affecting key neuronal RNAs.

The paper shows that transcription factors maintain CpG methylation during reprogramming of primordial germ cells and embryos, preserving epigenetic information across generations.