Anita H. Corbett

This study identifies a female-specific role for Nab2 in regulating insulin signaling and fat storage through neuronal control of dilp2 and dilp5 mRNA levels in Drosophila.

The paper systematically analyzes eight pathogenic EXOSC3 variants in yeast to determine their functional consequences on RNA exosome function.

The paper reports a patient with a neurodevelopmental disorder caused by biallelic EXOSC6 variants, expanding the known spectrum of exosomopathies.

This paper develops a Saccharomyces cerevisiae model to study how overexpression of the BER protein Ntg1 affects cell growth and DNA damage, revealing genetic interactions and regulatory mechanisms.

This paper shows that overexpressing Eaf1, a NuA4 subunit, rescues growth defects in yeast with H3K36M mutations by acetylating histone H4 tails.

The paper compares disease-linked missense mutations in the RNA exosome using yeast models to identify shared and distinct functional consequences in translation.

This paper identifies Nab2-regulated splicing of trio mRNA as critical for balancing Trio GEF domains and shaping axon and dendrite morphology in Drosophila neurons.

This paper identifies a biallelic EXOSC4 variant causing translational defects and a neurodevelopmental disorder through functional studies in yeast.

This study identifies Nab2's role in regulating m6A-dependent splicing of Sxl in Drosophila neuronal tissue, linking it to developmental and behavioral phenotypes.

The paper analyzes RNA exosome subunit transcript abundance across human tissues to understand their role in neurological diseases.

The paper characterizes a missense mutation in EXOSC2 that affects the RNA exosome-Mtr4 interaction in yeast, showing functional consequences in RNA processing and drug sensitivity.

The paper uses a budding yeast model to study the functional effects of oncogenic histone missense mutations and identifies suppressor genes involved in histone function and transcriptional regulation.

This study identifies genetic interactions between Nab2 and RNA exosome cofactors, revealing their role in regulating transcript stability through RNA-seq analysis.

This study identifies RNA interactomes of Drosophila Nab2 and Ataxin-2, showing they share RNA targets and regulate neuronal morphology.

This study shows Nab2 regulates dendritic arbors and axon projection through the planar cell polarity pathway in Drosophila.

The paper creates a yeast model of SHRF mutations in EXOSC2 and compares it to an EXOSC3 mutation model, showing distinct RNA exosome functional impacts.

This study shows ZC3H14 localizes to synapses, affects dendritic spine morphology, and dysregulates synaptic CaMKII levels upon loss of function.

The paper identifies genetic interactions between Nab2 and the planar cell polarity pathway in Drosophila, linking Nab2 to PCP-regulated processes like axon guidance and F-actin dynamics.

This study uses a Drosophila model to show that mutations in EXOSC3 cause neuronal dysfunction by altering RNA exosome function and affecting key neuronal RNAs.

The paper reports three patients with biallelic EXOSC5 variants causing developmental delays, short stature, and cerebellar hypoplasia, and shows functional defects in RNA exosome activity.