Application of Optogenetic Amyloid-β Distinguishes Between Metabolic and Physical Damage in Neurodegeneration
Lim Chu Hsien, Prameet Kaur, Emelyne Teo, Vanessa Yuk Man Lam, Fangchen Zhu, Caroline Kibat, Ajay Sriram Mathuru, Jan Gruber, Nicholas S. Tolwinski
This study uses optogenetic Amyloid-β to distinguish between metabolic and physical damage in Alzheimer's disease, showing that oligomerization causes severe tissue loss and that Li+ treatment reduces lifespan deficits.
bioRxiv · Nov 9, 2019 · PreprintDevelopmental Biology