Prameet Kaur

Junctional β-Catenin Stabilization Links Wnt Signaling and Force Generation

The paper measures β-catenin protein stability in vivo during development and finds stabilization at the leading edge during dorsal closure, linked to adhesion function and regulated by Dishevelled and JNK.

Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan

This study combines stem cell rejuvenation and senescent cell clearance to synergistically extend lifespan and improve healthspan in organisms.

A Non-Canonical Raf Function Is Required for Dorsal-Ventral Patterning During Drosophila Embryogenesis

This study identifies a non-canonical Raf function in Drosophila embryogenesis that is essential for dorsal-ventral patterning, independent of the MAPK cascade.

Application of Optogenetic Amyloid-β Distinguishes Between Metabolic and Physical Damage in Neurodegeneration

This study uses optogenetic Amyloid-β to distinguish between metabolic and physical damage in Alzheimer's disease, showing that oligomerization causes severe tissue loss and that Li+ treatment reduces lifespan deficits.

Coupling optogenetics and light-sheet microscopy to study signal transduction in vivo

The paper combines optogenetics and light-sheet microscopy to study Wnt signaling in Drosophila embryos, showing light-induced inhibition of Wnt signaling and its role in development.

An Embryonic System To Assess Wnt Transcriptional Targets

The paper develops an in vivo Drosophila assay to distinguish Wnt pathway transcriptional responses, identifying gene sets regulated by β-catenin, TCF, and non-canonical Wnt4.